Determining immunologic changes in the female genital tract and systemic changes among women initiating progestin-only contraceptives, and evaluating the role of the vaginal microenvironment as a potential modifiable risk-factor for changes in HIV susceptibility.
Advancing the development of a microarray patch delivering cabotegravir for prevention of HIV infection for up to 4 weeks of protection.
Testing a novel male contraceptive gel containing Nestorone and testosterone applied daily by the male partner in a global Phase 2 clinical trial evaluating the efficacy, safety and acceptability of the gel over a period of 52 weeks.
Developing a non-hormonal on-demand fast dissolving vaginal insert with a window of protection lasting 12 hours that could prevent HIV, other sexually transmitted infections, and pregnancy.
Innovating a low-cost highly-effective nonsurgical method of permanent contraception for women who have completed desired family size, with an appropriate delivery technology for low-resource settings.
Assessing the acceptability of a single pill for prevention of HIV and unintended pregnancy and testing whether a single pill increases adherence to oral pre-exposure prophylaxis (PrEP) compared with a pill providing PrEP alone.
Conducting a multi-site, open-label randomized clinical trial testing a 90-day contraceptive vaginal ring delivering Nestorone and estradiol, evaluating efficacy and bleeding control in continuous use and 2, 3, and 4-day ring-out regimens.
Supporting the development of a six-month contraceptive microarray patch by reviewing the applicator device, user studies, regulatory pathway, and preclinical activities.
Developing a 90-day vaginal ring that could prevent HIV infection, other sexually transmitted infections and pregnancy, and conducting behavioral studies to understand user-focused factors and promote adoption and use of this technology.
Evaluating safety and acceptability of a non surgical male circumcision device and providing evidence to inform prequalification by the World Health Organization and approval by the Food and Drug Administration.