Assessing the acceptability of a single pill for prevention of HIV and unintended pregnancy and testing whether a single pill increases adherence to oral pre-exposure prophylaxis (PrEP) compared with a pill providing PrEP alone.
Conducting a multi-site, open-label randomized clinical trial testing a 90-day contraceptive vaginal ring delivering Nestorone and estradiol, evaluating efficacy and bleeding control in continuous use and 2, 3, and 4-day ring-out regimens.
Supporting the development of a six-month contraceptive microarray patch by reviewing the applicator device, user studies, regulatory pathway, and preclinical activities.
Developing a 90-day vaginal ring that could prevent HIV infection, other sexually transmitted infections and pregnancy, and conducting behavioral studies to understand user-focused factors and promote adoption and use of this technology.
Evaluating safety and acceptability of a non surgical male circumcision device and providing evidence to inform prequalification by the World Health Organization and approval by the Food and Drug Administration.
Establishing potential biomarkers for use in household surveys as an easy and cost-effective approach for verifying assessments of contraceptive use and ultimately tracking progress toward increasing access to sexual and reproductive health services.
Determining immunologic changes in the female genital tract and systemic changes among women initiating progestin-only contraceptives, and evaluating the role of the vaginal microenvironment as a potential modifiable risk-factor for changes in HIV susceptibility.
Advancing the development of a microarray patch delivering cabotegravir for prevention of HIV infection for up to 4 weeks of protection.
Testing a novel male contraceptive gel containing Nestorone and testosterone applied daily by the male partner in a global Phase 2 clinical trial evaluating the efficacy, safety and acceptability of the gel over a period of 52 weeks.
Developing a non-hormonal on-demand fast dissolving vaginal insert with a window of protection lasting 12 hours that could prevent HIV, other sexually transmitted infections, and pregnancy.